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MYP_064874
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Basic Information
Lactoferricin B
Anticancer
Anticancer ▸ Apoptosis induction
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C141H226N46O29S3
Standard
Sequence
FKCRRWQWRMKKLGAPSITCVRRAF
Physicochemical Analysis
3125.79 Da
11.84
7.74
7.50
0.3095
-0.58
0.57
-0.31
77.92
50.80
0.1600
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1255.62
-9.15
50.0
40.0
103.0
219.0
7.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0142350 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas fluorescens
10 μg/mL
MIC
PMID8980754;9521752;1490908 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8980754/
RECORD: Rec_0148230 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-20
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer
S. enteritidis, Klebsiella pneumoniae JCM1662T
3 μM
MIC
PaperAntibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin.
RECORD: Rec_0149215 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella Salford
4 μg/mL
MIC
PMID8980754;9521752;1490908 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8980754/
RECORD: Rec_0155068 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferrin-derived
9913;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
19-36
Bio-Activity Profile
Antibiofilm Antifungal
Fusarium solani
20.489 μM
XTT assay
RECORD: Rec_0182860 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic Antileukemic Pro-apoptotic
Cytotoxic for leukemic cells
PaperApoptosis in Human Leukemic Cells Induced by Lactoferricin, a Bovine Milk Protein-Derived Peptide: Involvement of Reactive Oxygen Species | Yoo, Y-C. et al. | DOI: 10.1006/bbrc.1997.7199 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
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