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MYP_064874
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Basic Information
Lactoferricin B
Anticancer
Anticancer ▸ Apoptosis induction
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C141H226N46O29S3
Standard
Sequence
FKCRRWQWRMKKLGAPSITCVRRAF
Physicochemical Analysis
3125.79 Da
11.84
7.74
7.50
0.3095
-0.58
0.57
-0.31
77.92
50.80
0.1600
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1255.62
-9.15
50.0
40.0
103.0
219.0
7.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0071256 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory
PaperHayes M., Stanton C., Fitzgerald G.F., Ross R.P.. Putting microbes to work: Dairy fermentation, cell factories and bioactive peptides. Part II: Bioactive peptide functions. Biotechnol. J., 2 (2007), 435-449. PMID17407211 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17407211/
RECORD: Rec_0097969 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperHwang, P. M., Zhou, N., Shan, X., Arrowsmith, C. H., Vogel, H. J.. Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin. Biochemistry, 37, 4288-4298, 1998.
RECORD: Rec_0106077 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-20
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer
P. vulgaris, Y. enterocolitica, Pseudomonas aeruginosa IFO-3446
3 μM
MIC
PaperAntibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin.
RECORD: Rec_0107045 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID8980754;9521752;1490908 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8980754/
RECORD: Rec_0107649 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Pig erythrocytes
256000 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/21607695/ PMID21607695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21607695/
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