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MYP_064874
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Basic Information
Lactoferricin B
Anticancer
Anticancer ▸ Apoptosis induction
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C141H226N46O29S3
Standard
Sequence
FKCRRWQWRMKKLGAPSITCVRRAF
Physicochemical Analysis
3125.79 Da
11.84
7.74
7.50
0.3095
-0.58
0.57
-0.31
77.92
50.80
0.1600
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1255.62
-9.15
50.0
40.0
103.0
219.0
7.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0052806 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Transferrin
9913
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
12.5 μg/mL
MIC
PMID9521752;8980754 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9521752/
RECORD: Rec_0059648 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli; Staphylococcus aureus
30 μg/mL
MIC
PaperConstruction and synthesis of lactoferricin derivatives with enhanced antibacterial activity | Rekdal, O. et al. | DOI: 10.1002/(SICI)1099-1387(199901)5:1<32::AID-PSC172>3.0.CO;2-9 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
RECORD: Rec_0065646 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferrin-derived
9913;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Herpes simplex virus 1 (Virus entry); Vero
Viral titer
PaperPeptide inhibitors against herpes simplex virus infections. | Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M. | J Pept Sci. 2013 | PMID:23389903 PMID23389903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23389903/
RECORD: Rec_0068345 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
transferrin family
9913; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-20
Bio-Activity Profile
Antimicrobial transferrin family Antibacterial Antifungal Heparin-binding
PaperPDB 1Y58 structural record; NMR; chain A; residues 3-14
RECORD: Rec_0068417 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory Cytomodulatory
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