Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Standard StatusStandard

Sequence Length51 amino acids

Chemical FormulaC241H387N61O80S6

DescriptionStandard

        MIIMKNSKDVLNNAIEEVSEKELMEVAGGKKDSGWFATITDDCPNSVFVCC
    

Molecular Weight5611.40 Da

Isoelectric Point (pI)4.40

Net Charge (pH 7.0)-4.52

Net Charge (pH 7.4) -4.79

Charge Density (pH 7.0) -0.0885

GRAVY Index-0.05

Hydrophobic Moment 0.58

Boman Index0.07

Instability Index39.32

Aliphatic Index 80.20

Aromaticity 0.0588

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2284.86

LogP -22.99

H-bond Donors 79.0

H-bond Acceptors 82.0

Rotatable Bonds 192.0

Heavy Atoms 388.0

Ring Count 5.0

Amide Bonds 54.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0059436 VERIFIED: NO

Provenance & Taxonomy

OrganismLeuconostoc holzapfelii [Bacterium]

FamilyLantibiotic

Structure & Mods

Configthioether-cyclized lantibiotic scaffold [Cyclic]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLanthionine/methyllanthionine-type thioether crosslinks are implied by the lantibiotic annotation

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive

TargetGram-positive bacteria