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MYP_064642
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Standard
8 amino acids
C46H76N12O12
Standard
Sequence
KKYNVPQL
Physicochemical Analysis
989.17 Da
9.70
1.76
1.55
0.2196
-1.21
0.05
-0.26
56.90
85.00
0.1250
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
416.68
-2.65
13.0
14.0
32.0
70.0
2.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0284912 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]; Manchego cheese [Animal]
9913; 33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PMID20397194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20397194/
RECORD: Rec_0300902 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
77100 μM
IC50
PaperChanges in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats PMID20397194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20397194/
RECORD: Rec_0376690 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
alpha-S1-Casein-derived
9940
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
77.1 μM
IC50
PaperAngiotensin converting enzyme-inhibitory activity of peptides isolated from Manchego cheese Stability under simulated gastrointestinal digestion | Gomez-Ruiz, JA. et al. | DOI: 10.1016/j.idairyj.2004.04.007 Evidence URLhttps://www.uniprot.org/uniprotkb/P04653/entry
RECORD: Rec_0419617 VERIFIED: NO
Provenance & Taxonomy
Ovis aries [Animal]
9940
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
PaperAngiotensin-converting enzyme-inhibitory peptides in Manchego cheeses manufactured with different starter cultures
RECORD: Rec_0425062 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
11.5 mmHg
SBP decrease
PaperChanges in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats PMID20397194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20397194/
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