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MYP_064631
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Basic Information
Apelin-13
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
13 amino acids
C69H111N23O16S
Standard
Sequence
QRPRLSHKGPMPF
Physicochemical Analysis
1550.83 Da
12.00
2.85
2.59
0.2189
-1.32
0.45
-0.33
72.75
30.00
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
627.97
-5.71
21.0
21.0
47.0
109.0
5.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0178454 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Apelin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Bio-Activity Profile
Neuropeptide Hormone
Evidence URLhttps://www.uniprot.org/uniprotkb/APEL_BOVIN/entry
RECORD: Rec_0240508 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Apelin
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Bio-Activity Profile
Hormone Endocrine Cardiovascular Growth regulation Development regulation Myotropic Receptor modulation Immunomodulatory
response to T-cell receptor
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Apelin-13 (Bos taurus): PMID 9792798 PMID9792798 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9792798/
RECORD: Rec_0305017 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV | NP-2/CD4/APJ cells
16.77 μM
IC50
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperApelin peptides block the entry of human immunodeficiency virus (HIV). | Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. | FEBS Lett. 2000 May 4;473(1):15-8. | DOI:10.1016/s0014-5793(00)01487-3 | PMID:10802050 PMID10802050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10802050/
RECORD: Rec_0341074 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Apelin
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Bio-Activity Profile
Hormone Endocrine Cardiovascular Growth regulation Development regulation Myotropic Receptor modulation Immunomodulatory
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Apelin-13 (Bos taurus): PMID 9792798 PMID9792798 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9792798/
RECORD: Rec_0369636 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Apelin
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Myotropic Receptor modulation Immunomodulatory Feeding regulator
response to T-cell receptor
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Apelin-13 (Rattus norvegicus): PMID 15541902 PMID15541902 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15541902/
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