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MYP_064603
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Basic Information
Antimicrobial peptide Polydim-I
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C117H193N27O27S
Standard
Sequence
AVAGEKLWLLPHLLKMLLTPTP
Physicochemical Analysis
2442.01 Da
8.64
0.88
0.64
0.0402
0.65
0.45
0.35
38.35
146.36
0.0455
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
822.32
-0.93
27.0
30.0
75.0
172.0
6.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0236175 VERIFIED: YES
Provenance & Taxonomy
Polybia dimorpha [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-positive Anti-Gram-negative
Refer PubMed 28570651: Staphylococcus aureus
4.1 μg/mL
MIC50
PMID30974767;28570651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30974767/
RECORD: Rec_0283872 VERIFIED: YES
Provenance & Taxonomy
Polybia dimorpha [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii Isolate AB 53
25 μM
MIC
PMID30974767;28570651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30974767/
RECORD: Rec_0294447 VERIFIED: YES
Provenance & Taxonomy
Polybia dimorpha [Animal]
Natural peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium abscessus subsp. massiliense isolates GO 01, GO 06, GO 07, GO 08, GO 13, and GO 18, CRM0020 (Mycobacterium abscessus subsp. massiliense), and ATCC 19977 (Mycobacterium abscessus subsp. abscessus)
60.8 μg/mL
MIC
PMID26930596 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26930596/
RECORD: Rec_0393520 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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