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MYP_064603
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Basic Information
Antimicrobial peptide Polydim-I
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C117H193N27O27S
Standard
Sequence
AVAGEKLWLLPHLLKMLLTPTP
Physicochemical Analysis
2442.01 Da
8.64
0.88
0.64
0.0402
0.65
0.45
0.35
38.35
146.36
0.0455
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
822.32
-0.93
27.0
30.0
75.0
172.0
6.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0134367 VERIFIED: YES
Provenance & Taxonomy
Polybia dimorpha [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
400 μg/mL
MIC
PMID30974767;28570651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30974767/
RECORD: Rec_0181260 VERIFIED: YES
Provenance & Taxonomy
Polybia dimorpha [Animal]
Polydim
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperPLoS One. 2016 Mar 1;11(3):e0149729 | https://www.ncbi.nlm.nih.gov/pubmed/26930596 PMID26930596 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26930596/
RECORD: Rec_0195127 VERIFIED: YES
Provenance & Taxonomy
Polybia dimorpha [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-positive Anti-Gram-negative
Escherichia coli
50.7 μg/mL
MIC50
PMID30974767;28570651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30974767/
RECORD: Rec_0202746 VERIFIED: NO
Provenance & Taxonomy
Polybia dimorpha [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Cytotoxic Hemolytic Non-ribosomal
Qualitative functional evidence
PMID26930596 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26930596/; https://www.uniprot.org/uniprotkb/P0DV63/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0225838 VERIFIED: YES
Provenance & Taxonomy
Polybia dimorpha [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis
73.2 μg/mL
MIC50
PMID30974767;28570651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30974767/
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