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MYP_064538
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Basic Information
T21N36
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
59 amino acids
C312H526N100O87
Standard
Sequence
RIQQIEQKIHHIEQRIQQIEQRISGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL
Physicochemical Analysis
7070.13 Da
10.78
3.03
2.67
0.0514
-0.45
0.63
-0.10
87.91
133.90
0.0169
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3136.68
-28.26
104.0
93.0
254.0
499.0
5.0
75.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0151101 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 (human immunodeficiency virus 1) | TZM-bl cells; HL2/3 cells
0.0818±0.00569 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperSuitable fusion of N-terminal heptad repeats to achieve covalently stabilized potent N-peptide inhibitors of HIV-1 infection. | Lai W, Wang C, Yan J, Liu H, Zhang W, Lin B, Xi Z. | Bioorg Med Chem. 2020 Feb 15;28(4):115214. | DOI:10.1016/j.bmc.2019.115214 | PMID:31932193 PMID31932193 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31932193/
RECORD: Rec_0246957 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1(human immunodeficiency virus 1):inhiition of cell-cell fusion between TZM-bl cells and HL2/3 cells
0.0818±0.00569 μM
IC50
PMID31932193 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31932193/
RECORD: Rec_0301661 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
PMID31932193 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31932193/