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MYP_064501
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Basic Information
A (I17R) (Derived from AR-23)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
23 amino acids
C111H191N33O28
Standard
Sequence
AIGSILGALAKGLPTLRSWIKNR
Physicochemical Analysis
2435.91 Da
12.00
3.79
3.60
0.1650
0.34
0.58
0.15
42.72
131.74
0.0435
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
990.14
-8.40
36.0
32.0
81.0
172.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018309 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0053665 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0053800 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
10 % hemolysis at 25 μM
Hemolysis
PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0066039 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus CGMCC 1.8721
25 μM
MIC
PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0070968 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus epidermidis CGMCC 1.4260
6.25 μM
MIC
PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
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