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MYP_064436
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Basic Information
Plantazolicin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
14 amino acids
C61H103N17O23S2
Standard
Sequence
RCTCTTIISSSSTF
Physicochemical Analysis
1506.70 Da
8.07
0.74
0.51
0.0529
0.45
0.26
0.08
105.94
55.71
0.0714
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
665.36
-11.35
28.0
26.0
47.0
103.0
1.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0167570 VERIFIED: YES
Provenance & Taxonomy
Bacillus amyloliquefaciens [Bacterium],Bacillus pumilus [Bacterium]
Bacteriocin
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
10 residues (Cys, Ser/Thr) potentially serve as a site of heterocycle formation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis strain 168
PMID20971906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20971906/
RECORD: Rec_0168907 VERIFIED: YES
Provenance & Taxonomy
Bacillus amyloliquefaciens [Bacterium],Bacillus pumilus [Bacterium]
Bacteriocin
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
10 residues (Cys, Ser/Thr) potentially serve as a site of heterocycle formation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus anthracis
2-4 μg/mL
MIC
PMID20971906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20971906/
RECORD: Rec_0210924 VERIFIED: YES
Provenance & Taxonomy
Bacillus amyloliquefaciens [Bacterium],Bacillus pumilus [Bacterium]
Bacteriocin
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
10 residues (Cys, Ser/Thr) potentially serve as a site of heterocycle formation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Paenibacillus granivorans and Streptococcus pyogenes
128 μg/mL
MIC
PMID20971906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20971906/
RECORD: Rec_0220910 VERIFIED: YES
Provenance & Taxonomy
Bacillus amyloliquefaciens FZB42 [Bacterium]
Plantazolicin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus brevis ATCC 8246, Bacillus subtilis 168, Bacillus cereus ATCC 14579, Bacillus licheniformis ATCC 9789, Micrococcus luteus, Bacillus subtilis CU1065, Bacillus subtilis HB0042, Bacillus sphaericus, Paenibacillus granivorans, Bacillus megaterium 7A1; Bacillus anthracis
128 μg/mL
MIC
PMID20971906;21950656 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20971906/
RECORD: Rec_0225532 VERIFIED: YES
Provenance & Taxonomy
Bacillus amyloliquefaciens [Plant]
Microcin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Extensive post-translation is predicted but not characterized yet. The peptide displays antibacterial activity towards closely related gram-positive bacteria. A cluster of twelve genes that covers ~10 kb is essential for the production, modification, export, and self immunity of this natural product. The amino-terminus of PZN has been modified to N(alpha),N(alpha)-dimethylarginine. The peptide has highly selective antibiotic activity against B. anthracis ACS Chem Biol 2011 by targeting membranes (Molohon KJ et al., 2016). Found in multiple species. APD update 11/2010; 7/2012; 7/2016
Bio-Activity Profile
Antimicrobial
PaperPlantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42
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