Peptide Database

Peptide NameNivolumab

Function Ontology

Anticancer

Immunology ▸ Immune checkpoint modulation ▸ Immune checkpoint inhibitor

Immunology ▸ Immunomodulation ▸ Immunotherapy

Standard StatusStandard

Sequence Length60 amino acids

Chemical FormulaC297H457N85O84S2

DescriptionStandard

        QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYY
    

Molecular Weight6626.45 Da

Isoelectric Point (pI)9.43

Net Charge (pH 7.0)2.84

Net Charge (pH 7.4) 2.56

Charge Density (pH 7.0) 0.0473

GRAVY Index-0.28

Hydrophobic Moment 0.55

Boman Index0.04

Instability Index47.79

Aliphatic Index 77.83

Aromaticity 0.1167

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 20970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2731.30

LogP -27.08

H-bond Donors 98.0

H-bond Acceptors 90.0

Rotatable Bonds 215.0

Heavy Atoms 468.0

Ring Count 13.0

Amide Bonds 64.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0254499 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMonoclonal antibody

Tax ID9606

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunotherapy Immune checkpoint inhibitor

Half-Life26.7 d

PaperPubMed-linked source references: PMID:25765457; PMID:28318993; PMID:28317087; PMID:28314688; PMID:28314298; PMID:28306559; PMID:28304223; PMID:28303763; PMID:28303522 PMID25765457;28318993;28317087;28314688;28314298;28306559;28304223;28303763;28303522 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25765457/ PatentUS2013173223