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MYP_064286
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Basic Information
Esculentin-2SE
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
37 amino acids
C173H297N45O46S3
Standard
Sequence
GFFSLIKGVAKIATKGLAKNLGKMGLDLVGCKISKEC
Physicochemical Analysis
3839.68 Da
9.70
4.74
4.49
0.1280
0.44
0.66
0.18
14.35
108.11
0.0541
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1471.44
-12.04
53.0
54.0
138.0
267.0
2.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0353779 VERIFIED: YES
Provenance & Taxonomy
Rana sevosa [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
31-37
Bio-Activity Profile
Antimicrobial
PaperHistamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa
RECORD: Rec_0399876 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Frog skin active peptide (FSAP); Esculentin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Anti-Gram-negative Non-hemolytic
Escherichia coli (Gram-negative)
PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
RECORD: Rec_0416839 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Esculentin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Mast cell degranulation Histamine releasing
PaperC. Graham et al. / Peptides 27 (2006) 1313-1319. Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa Evidence URLhttps://www.uniprot.org/uniprotkb/P85055/entry
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