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MYP_064286
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Basic Information
Esculentin-2SE
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
37 amino acids
C173H297N45O46S3
Standard
Sequence
GFFSLIKGVAKIATKGLAKNLGKMGLDLVGCKISKEC
Physicochemical Analysis
3839.68 Da
9.70
4.74
4.49
0.1280
0.44
0.66
0.18
14.35
108.11
0.0541
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1471.44
-12.04
53.0
54.0
138.0
267.0
2.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0182719 VERIFIED: YES
Provenance & Taxonomy
Rana sevosa [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus NCT C2665
PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
RECORD: Rec_0210995 VERIFIED: YES
Provenance & Taxonomy
Lithobates capito [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PMID19635516 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19635516/
RECORD: Rec_0289624 VERIFIED: YES
Provenance & Taxonomy
Lithobates capito [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
25 μM
MIC
PMID19635516 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19635516/
RECORD: Rec_0314496 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0352623 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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