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MYP_064286
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Basic Information
Esculentin-2SE
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
37 amino acids
C173H297N45O46S3
Standard
Sequence
GFFSLIKGVAKIATKGLAKNLGKMGLDLVGCKISKEC
Physicochemical Analysis
3839.68 Da
9.70
4.74
4.49
0.1280
0.44
0.66
0.18
14.35
108.11
0.0541
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1471.44
-12.04
53.0
54.0
138.0
267.0
2.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0013171 VERIFIED: YES
Provenance & Taxonomy
Rana sevosa [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli K12
PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
RECORD: Rec_0065475 VERIFIED: YES
Provenance & Taxonomy
Lithobates capito [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
50 μM
MIC
PMID19635516 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19635516/
RECORD: Rec_0134034 VERIFIED: YES
Provenance & Taxonomy
Lithobates capito [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
25 μM
MIC
PMID19635516 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19635516/
RECORD: Rec_0142677 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Frog skin active peptide (FSAP); Esculentin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Anti-Gram-negative Non-hemolytic
Micrococcus luteus (Gram-negative)
PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
RECORD: Rec_0180750 VERIFIED: NO
Provenance & Taxonomy
Rana sevosa [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli and, Mycobacterium luteus
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