‹ ›
MYP_064284
← PREVIOUS NEXT → BACK
Basic Information
Brevinin-1H
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C109H185N27O24S2
Standard
Sequence
FALGAVTKVLPKLFCLITRKC
Physicochemical Analysis
2321.93 Da
9.85
3.74
3.50
0.1780
1.08
0.64
0.26
11.70
130.00
0.0952
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
816.95
-3.43
31.0
30.0
76.0
162.0
3.0
20.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0341104 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hainan cascade-frog [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
the proliferation of multiple cancer cell lines H157, PC-3, MB435S and HCT116 human cancer cell lines
3.4-5.9 μM
IC50
PaperCharacterisation of a novel peptide, Brevinin-1H, from the skin secretion of Amolops hainanensis and rational design of several analogues
RECORD: Rec_0342812 VERIFIED: YES
Provenance & Taxonomy
Amolops hainanensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Horse erythrocytes
9.49 % Hemolysis
Hemolysis
PMID32812694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32812694/
RECORD: Rec_0362548 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Amolops hainanensis [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
PC-3
5.87 μM
IC50
PaperPubMed PMID: 32812694 PMID32812694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32812694/
RECORD: Rec_0364516 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hainan cascade-frog [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
aeruginosa,. and Klebsiella pneumoniae, indicating resudue P plays a role in determinting peptide activity spectrum. Brevinin-1Ha is poorly hemolytic, while Brevinin-1HY is more hemolytic
~6 μM
HC50
PaperCharacterisation of a novel peptide, Brevinin-1H, from the skin secretion of Amolops hainanensis and rational design of several analogues
RECORD: Rec_0366441 VERIFIED: YES
Provenance & Taxonomy
Amolops hainanensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli NCTC 10418
16 μM
MIC
PMID32812694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32812694/
FIRST PREV 1 ... 4 5 6 7 NEXT LAST
Showing 5 records on this page · Page 6 of 7