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MYP_064284
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Basic Information
Brevinin-1H
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C109H185N27O24S2
Standard
Sequence
FALGAVTKVLPKLFCLITRKC
Physicochemical Analysis
2321.93 Da
9.85
3.74
3.50
0.1780
1.08
0.64
0.26
11.70
130.00
0.0952
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
816.95
-3.43
31.0
30.0
76.0
162.0
3.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0311785 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hainan cascade-frog [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Pseudomonas aeruginosa
64 μM
MIC
PaperCharacterisation of a novel peptide, Brevinin-1H, from the skin secretion of Amolops hainanensis and rational design of several analogues
RECORD: Rec_0320287 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hainan cascade-frog [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Klebsiella pneumoniae
64 μM
MIC
PaperCharacterisation of a novel peptide, Brevinin-1H, from the skin secretion of Amolops hainanensis and rational design of several analogues
RECORD: Rec_0322220 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Amolops hainanensis [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 32812694 PMID32812694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32812694/
RECORD: Rec_0331627 VERIFIED: YES
Provenance & Taxonomy
Amolops hainanensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human breast adenocarcinoma MDA-MB-435S
3.47 μM
IC50
PMID32812694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32812694/
RECORD: Rec_0334799 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Amolops hainanensis [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HCT 116
2.599 μM
IC50
PaperPubMed PMID: 32812694 PMID32812694 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32812694/
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