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MYP_064183
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Basic Information
Gramicidin A
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Wound healing/Regeneration ▸ Wound healing
Standard
15 amino acids
C96H135N19O16
Standard
Sequence
VGALAVVVWLWLWLW
Physicochemical Analysis
1811.22 Da
5.50
-0.27
-0.48
-0.0177
2.11
0.08
0.90
70.05
194.67
0.2667
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
533.88
5.56
20.0
16.0
49.0
131.0
8.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0022477 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
PMID19870884 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19870884/
RECORD: Rec_0029567 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Peptide antibiotic
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Formylation
Hydroxyethyl amide
Four tryptophans of gramicidin A modified with formic acid
Bio-Activity Profile
Antimicrobial Antibiotic Antiparasitic Antimalarial
Plasmodium berghei
0.021 μM
Percent inhibition; Microscopy (Giemsa staining)
PMID9257760 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9257760/
RECORD: Rec_0060962 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Diplococcus pneumoniae
PMID19870884 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19870884/
RECORD: Rec_0068668 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0072731 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Peptide antibiotic
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Formylation
Hydroxyethyl amide
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum
0.035 μM
IC50; [3H] Hypoxanthine incorporation assay
PMID8851578 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8851578/
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