Peptide Database

Peptide NameBrevinin-ALb (Amolopin-1b) (Brevinin-1E-AL2)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length70 amino acids

Chemical FormulaC366H592N92O108S5

DescriptionStandard

        MFTLKKSLLLLFFLGTINLSLCEQERDADEEERRDDDEMDVEVEKRFLPLAVSLAANFLPKLFCKITKKC
    

Molecular Weight8169.49 Da

Isoelectric Point (pI)4.88

Net Charge (pH 7.0)-3.51

Net Charge (pH 7.4) -3.79

Charge Density (pH 7.0) -0.0501

GRAVY Index-0.09

Hydrophobic Moment 0.68

Boman Index-0.04

Instability Index34.81

Aliphatic Index 101.71

Aromaticity 0.0857

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3256.23

LogP -23.16

H-bond Donors 114.0

H-bond Acceptors 110.0

Rotatable Bonds 284.0

Heavy Atoms 571.0

Ring Count 8.0

Amide Bonds 72.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0037518 VERIFIED: YES

Provenance & Taxonomy

OrganismAmolops loloensis [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Cytotoxic Hemolytic

TargetCandida albicans

RECORD: Rec_0063721 VERIFIED: YES

Provenance & Taxonomy

OrganismAmolops loloensis [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Cytotoxic Hemolytic

TargetEscherichia coli

RECORD: Rec_0264213 VERIFIED: YES

Provenance & Taxonomy

OrganismAmolops loloensis [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Cytotoxic Hemolytic

TargetStaphylococcus aureus