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MYP_063924
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Basic Information
17BIPHE2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
17 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GXKRLVQRLKDXLRNLV
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0315009 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
biphenylalanines at 2,12; biphenylalanines
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii B28-16
4-8 μM
MIC
PMID34959645 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34959645/
RECORD: Rec_0348948 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Free; Non-standard residue B
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25293
8 μM
MIC
Paper抗菌肽17BIPHE2对金黄色葡萄球菌生物被膜的抑制作用; Inhibition of Staphylococcus aureus biofilm by antimicrobial peptide 17BIPHE2. [J].微生物学通报,2017,44(04):872-880. DOI:10.13344/j.microbiol.china.160394. Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP37208
RECORD: Rec_0357259 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L. at 2,12; biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
3.1 μM
MIC
PMID30800727 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30800727/
RECORD: Rec_0385962 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L. at 2,12; biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa PAO1
6.2 μM
MIC
PMID30800727 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30800727/
RECORD: Rec_0391772 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
biphenylalanines at 2,12; biphenylalanines
Bio-Activity Profile
Hemolytic
Human RBC
200 μM
Hemolysis
PMID34959645 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34959645/
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