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MYP_063924
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Basic Information
17BIPHE2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
17 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GXKRLVQRLKDXLRNLV
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0357259 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
ambiguous/noncanonical residue annotation [Modified]
biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L. at 2,12; biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
3.1 μM
MIC
PMID30800727 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30800727/
RECORD: Rec_0385962 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
ambiguous/noncanonical residue annotation [Modified]
biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L. at 2,12; biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa PAO1
6.2 μM
MIC
PMID30800727 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30800727/
RECORD: Rec_0391772 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
biphenylalanines at 2,12; biphenylalanines
Bio-Activity Profile
Hemolytic
human red blood cells
200 μM
Hemolysis
PMID34959645 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34959645/
RECORD: Rec_0407783 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'X' at position 2 and 12 indicates biphenylalanine
Bio-Activity Profile
Antimicrobial Antiviral
PMID32252021 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32252021/
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