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MYP_063924
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Basic Information
17BIPHE2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
17 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GXKRLVQRLKDXLRNLV
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0234728 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Contains X placeholder residue(s)
Bio-Activity Profile
Antimicrobial Antibacterial
PaperPatent US 10723764 B2 Evidence URLhttps://patents.google.com/patent/US10723764B2/en PatentUS 10723764 B2
RECORD: Rec_0251945 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'X' at position 2 and 12 indicates biphenylalanine.
Bio-Activity Profile
Antiviral Anti-EBOV Entry inhibition
Ebola Virus (EBOV) | Hela cells
0.71 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperEngineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection. | Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K. | iScience. 2020 Apr 24;23(4):100999. | DOI:10.1016/j.isci.2020.100999 | PMID:32252021 PMID32252021 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32252021/
RECORD: Rec_0295103 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
biphenylalanines at 2,12; biphenylalanines
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
E. faecium V284-17
2 μM
MIC
PMID34959645 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34959645/
RECORD: Rec_0302404 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'X' at position 2 and 12 indicates biphenylalanine
Bio-Activity Profile
Antimicrobial Antiviral
Ebola Virus(EBOV):inhibition of viral infection in Hela cells
0.71 μM
IC50
PMID32252021 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32252021/
RECORD: Rec_0313317 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Free; Non-standard residue B
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus 05
8 μM
MIC
Paper抗菌肽17BIPHE2对金黄色葡萄球菌生物被膜的抑制作用; Inhibition of Staphylococcus aureus biofilm by antimicrobial peptide 17BIPHE2. [J].微生物学通报,2017,44(04):872-880. DOI:10.13344/j.microbiol.china.160394. Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP37208
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