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MYP_063924
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Basic Information
17BIPHE2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
17 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GXKRLVQRLKDXLRNLV
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0158462 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
LL-37
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
Free; Non-standard residue B
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus gordonii
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP37260
RECORD: Rec_0171064 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'X' at position 2 and 12 indicates biphenylalanine.
Bio-Activity Profile
Antiviral Entry inhibition
inhibition of viral infection in primary macrophages
5.6 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperEngineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection. | Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K. | iScience. 2020 Apr 24;23(4):100999. | DOI:10.1016/j.isci.2020.100999 | PMID:32252021 PMID32252021 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32252021/
RECORD: Rec_0191410 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L. at 2,12; biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L.
Bio-Activity Profile
Hemolytic
Human RBC
110 μM
Hemolysis
PMID30800727 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30800727/
RECORD: Rec_0224800 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L. at 2,12; biphenylalanine, L at positions 20,24,28 ane D-amino acids instead of L.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus USA300
3.1 μM
MIC
PMID30800727 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30800727/
RECORD: Rec_0226605 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
biphenylalanines at 2,12; biphenylalanines
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus USA300
4 μM
MIC
PMID34959645 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34959645/
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