Peptide Database

Peptide NameSLAY-screened peptide P5478

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC114H159N27O28

DescriptionStandard

        AGFIHPYFPRLIVATFNDNY
    

Molecular Weight2355.65 Da

Isoelectric Point (pI)6.79

Net Charge (pH 7.0)-0.12

Net Charge (pH 7.4) -0.36

Charge Density (pH 7.0) -0.0059

GRAVY Index0.20

Hydrophobic Moment 0.52

Boman Index0.28

Instability Index22.02

Aliphatic Index 83.00

Aromaticity 0.2500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 873.39

LogP -4.45

H-bond Donors 29.0

H-bond Acceptors 29.0

Rotatable Bonds 67.0

Heavy Atoms 169.0

Ring Count 8.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0351389 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/