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MYP_063890
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Basic Information
Tricyclon A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
33 amino acids
C149H219N37O49S6
Standard
Sequence
GGTIFDCGESCFLGTCYTKGCSCGEWKLCYGTN
Physicochemical Analysis
3504.94 Da
4.68
-1.30
-1.60
-0.0393
0.01
0.37
0.17
11.08
35.45
0.1515
8480.00
8855.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1379.18
-17.00
55.0
54.0
111.0
241.0
6.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0278642 VERIFIED: YES
Provenance & Taxonomy
Viola odorata L. and Viola tricolor L [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
80 μM
MIC
PMID28669767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
RECORD: Rec_0281833 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
cyclotide family
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
7-21; 11-23; 16-29
Bio-Activity Profile
Other cyclotide family Host defense
PaperPDB 1YP8 structural record; NMR; chain A; residues 7-33
RECORD: Rec_0284778 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Antiviral Hemolytic
Candida albicans
40 μM
MIC
PaperPeptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining | PubMed PMID 28669767 PMID28669767;26399490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
RECORD: Rec_0288606 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Antiviral Hemolytic Anti-Gram-negative
Pseudomonas aeruginosa
80 μM
MIC
PaperPeptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining | PubMed PMID 28669767 PMID28669767;26399490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
RECORD: Rec_0297693 VERIFIED: YES
Provenance & Taxonomy
Australian flowers [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Pseudomonas aeruginosa
80 μM
MIC
PaperProcessing of a 22 kDa precursor protein to produce the circular protein tricyclon A.
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