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MYP_063890
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Basic Information
Tricyclon A
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
33 amino acids
C149H219N37O49S6
Standard
Sequence
GGTIFDCGESCFLGTCYTKGCSCGEWKLCYGTN
Physicochemical Analysis
3504.94 Da
4.68
-1.30
-1.60
-0.0393
0.01
0.37
0.17
11.08
35.45
0.1515
8480.00
8855.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1379.18
-17.00
55.0
54.0
111.0
241.0
6.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0211678 VERIFIED: NO
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://www.uniprot.org/uniprotkb/P0C589/entry
RECORD: Rec_0217776 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0218761 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Antiviral Hemolytic Anti-Gram-negative
Pseudomonas aeruginosa
40 μM
MIC
PaperPeptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining | PubMed PMID 28669767 PMID28669767;26399490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
RECORD: Rec_0223286 VERIFIED: YES
Provenance & Taxonomy
Australian flowers [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Candida albicans
80 μM
MIC
PaperProcessing of a 22 kDa precursor protein to produce the circular protein tricyclon A.
RECORD: Rec_0224524 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Antiviral Hemolytic
Human histiocytic lymphoma U-937/GTB
8.7 μM
IC50
PaperPeptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining | PubMed PMID 28669767 PMID28669767;26399490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
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