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MYP_063768
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Basic Information
Brevinin-1CHa (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
24 amino acids
C122H206N28O26S2
Standard
Sequence
FLPIIAGVAAKVLPKLFCAITKKC
Physicochemical Analysis
2545.24 Da
9.70
3.74
3.50
0.1557
1.30
0.58
0.40
18.56
138.33
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
839.35
-1.90
30.0
32.0
82.0
178.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0021555 VERIFIED: YES
Provenance & Taxonomy
Rana chiricahuensis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Streptococcus pneumoniae
40 μM
MIC
PMID17938991;21262304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17938991/
RECORD: Rec_0077762 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
5.0 μM
HC50
PaperJ.M. Conlon et al. / Peptides 32 (2011) 664-669. Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona
RECORD: Rec_0115243 VERIFIED: YES
Provenance & Taxonomy
Chiricahua leopard [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
PMID21262304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21262304/
RECORD: Rec_0161495 VERIFIED: YES
Provenance & Taxonomy
Rana chiricahuensis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
2.5 μM
MIC
PMID17938991;21262304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17938991/
RECORD: Rec_0162365 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
PaperJ.M. Conlon et al. / Peptides 32 (2011) 664-669. Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona
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