Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length485 amino acids

Chemical FormulaC2438H3900N632O682S15

DescriptionStandard

        TKMARGPDDTWRWATLVVLAALGTAVTATTSPGVVARITQKGLDYACQQGVTTLQKELEKVTIPTFSGSFKMKYLGKGKYSFYSLVIREFKLPNSQIRPSPGQDLDLSVKDASIKMSGKWKARKNFIKVSGNFDLSVEGISILAGLKLGYDPTSGHPTVTCSSCSSHVNSVRVRISRSSLGWLIQLFRKKIESLLRNSMNRKICKVVTSTVSSKLQPYFQTLPVTTKIDNVAGIDYSLVAPPKATADNLDVLLKGEFFRLAHRGPPPFAPPALTLPNDHNRMVYLAISEYLFNTAGLVYQEAGVLNFTLSDDTLPKESKFLLTTKSFGTLLPQVAKMFPDMKMQLLIWVSSPPNIAVCPTGLHLTFALDTQAVAVRPDSSLAPLFLLEMYVNVSVDIGARSDRLVGELKLDKLLLELKHSDVGPFPVELLQTIMNYVVPTVVIPKINKKLQKGFPLPLPASIQLFNLVLQPHQDFLLFGADVRYS
    

Molecular Weight53457.85 Da

Isoelectric Point (pI)9.56

Net Charge (pH 7.0)17.97

Net Charge (pH 7.4) 17.24

Charge Density (pH 7.0) 0.0371

GRAVY Index0.06

Hydrophobic Moment 0.74

Boman Index0.10

Instability Index36.55

Aliphatic Index 101.26

Aromaticity 0.0845

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0183081 VERIFIED: NO

Provenance & Taxonomy

OrganismPhocoena sinus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence