Peptide Database

Peptide NameSLAY-screened peptide P2992

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC99H155N33O32S

DescriptionStandard

        HCRSSGFNKNPDIYTLSARAN
    

Molecular Weight2351.56 Da

Isoelectric Point (pI)9.31

Net Charge (pH 7.0)1.84

Net Charge (pH 7.4) 1.56

Charge Density (pH 7.0) 0.0875

GRAVY Index-0.92

Hydrophobic Moment 0.32

Boman Index-0.23

Instability Index41.89

Aliphatic Index 46.67

Aromaticity 0.0952

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1082.75

LogP -15.44

H-bond Donors 39.0

H-bond Acceptors 36.0

Rotatable Bonds 75.0

Heavy Atoms 165.0

Ring Count 4.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0076936 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/