Peptide Database

Peptide NameSLAY-screened peptide P1194

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC87H147N33O29

DescriptionStandard

        PLKGLLVGHRASNDNSNNGR
    

Molecular Weight2119.30 Da

Isoelectric Point (pI)10.84

Net Charge (pH 7.0)2.05

Net Charge (pH 7.4) 1.94

Charge Density (pH 7.0) 0.1023

GRAVY Index-1.03

Hydrophobic Moment 0.48

Boman Index-0.24

Instability Index-10.75

Aliphatic Index 78.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1030.85

LogP -15.68

H-bond Donors 36.0

H-bond Acceptors 32.0

Rotatable Bonds 72.0

Heavy Atoms 149.0

Ring Count 2.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0423448 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/