Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length509 amino acids

Chemical FormulaC2601H4083N653O736S18

DescriptionStandard

        TKMAQVQVLWGCILLWNLYISSAQAIYPGIKARATQRALDYAVQAGMEMIEQMAKERKLPDLKGSESLEFLKIDYVNYNFTIKSNIKIKTFRFPGVSVCDRIIITYRKAHGHRTVSVACHLTLTVFLNQDTGAADLFLSGVYFTGIVVLSRNDFGHPILKLQDCYAQVSHADVSFSGELSVLYNSFAEPMEKPILKKLNEMLCPIITGEVEALNANLSMLEVLRKIDNYTLLDYSLVSSPEITEDYFDLNLKGVFYPLKTLQYPPFPSVPFVLPERSDSMLYVGISKYFFKSASYAYFTAGAFSFTLTTKEISNHLLHNSQALGNMLTRIAELYILSQPFMVQVTATEPPVISLLPGNFTLDIPASIMILTQPKNSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFRLSLPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSKQQPGFLGWEGLHLISGQWSGKPTP
    

Molecular Weight56854.34 Da

Isoelectric Point (pI)7.09

Net Charge (pH 7.0)0.25

Net Charge (pH 7.4) -0.65

Charge Density (pH 7.0) 0.0005

GRAVY Index0.15

Hydrophobic Moment 0.68

Boman Index0.15

Instability Index38.51

Aliphatic Index 104.97

Aromaticity 0.1022

Extinction Coeff. Reduced 51800.00

Extinction Coeff. Oxidized 52175.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0250441 VERIFIED: NO

Provenance & Taxonomy

OrganismOvis aries [Animal]

FamilyBPI/LBP

Tax ID9940

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence