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MYP_063574
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Basic Information
Caerin 1.1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
25 amino acids
C121H202N32O30
Standard
Sequence
GLLSVLGSVAKHVLPHVVPVIAEHL
Physicochemical Analysis
2585.09 Da
7.02
0.02
-0.33
0.0009
1.19
0.47
0.47
29.70
171.20
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
933.96
-4.56
31.0
33.0
80.0
183.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0344301 VERIFIED: YES
Provenance & Taxonomy
Litoria caerulea [Animal]
Caerin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Anticancer nNOS inhibitor
PaperR.J. Jackway et al. / Peptides 32 (2011) 161-172. Skin peptide and cDNA profiling of Australian anurans: genus and species identification and evolutionary trends Evidence URLhttps://www.uniprot.org/uniprotkb/Q800R2/entry
RECORD: Rec_0346104 VERIFIED: YES
Provenance & Taxonomy
Litoria rothii [Animal]
Frog skin active peptide (FSAP); Caerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Non-hemolytic
PMID16124032;19539637 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16124032/
RECORD: Rec_0361587 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral
inhibition of HIV transfer by dendritic cells to T cells
12.6 μM
IC50
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID16140737;9266696;12709067;15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16140737/
RECORD: Rec_0365124 VERIFIED: NO
Provenance & Taxonomy
Magnificent tree [Animal]
Caerin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0365213 VERIFIED: YES
Provenance & Taxonomy
Ranoidea splendida [Animal]
Frog skin active peptide (FSAP); Caerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Non-hemolytic
No Target Organism Found
PMID9266696;11784303 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9266696/
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