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MYP_063574
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Basic Information
Caerin 1.1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
25 amino acids
C121H202N32O30
Standard
Sequence
GLLSVLGSVAKHVLPHVVPVIAEHL
Physicochemical Analysis
2585.09 Da
7.02
0.02
-0.33
0.0009
1.19
0.47
0.47
29.70
171.20
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
933.96
-4.56
31.0
33.0
80.0
183.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0304041 VERIFIED: NO
Provenance & Taxonomy
Litoria splendida [Animal] [Animal]; Litoria gilleni [Animal] [Animal]; Litoria caerulea [Animal] [Animal]; Litoria ewingi [Animal] [Animal]; Litoria gracilenta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
RECORD: Rec_0308488 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Caerin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Anti-Gram-positive Anti-Gram-negative
Bacillus cereus
50 μg/mL
MIC
PMID10601876;34259550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10601876/
RECORD: Rec_0320980 VERIFIED: YES
Provenance & Taxonomy
Litoria raniformis [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
115 μM
MIC
PMID28478484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28478484/
RECORD: Rec_0322575 VERIFIED: NO
Provenance & Taxonomy
Ranoidea gilleni [Animal]
Frog skin active peptide (FSAP); Caerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Non-hemolytic
No Target Organism Found
RECORD: Rec_0323698 VERIFIED: YES
Provenance & Taxonomy
Litoria rothii [Animal]
Australian green tree frogLitoria splendida; Litoria rothii
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
Lung Cancer (Not Available)
PaperThe solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida PMID9266696;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9266696/
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