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MYP_063574
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Basic Information
Caerin 1.1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
25 amino acids
C121H202N32O30
Standard
Sequence
GLLSVLGSVAKHVLPHVVPVIAEHL
Physicochemical Analysis
2585.09 Da
7.02
0.02
-0.33
0.0009
1.19
0.47
0.47
29.70
171.20
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
933.96
-4.56
31.0
33.0
80.0
183.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0220546 VERIFIED: YES
Provenance & Taxonomy
Australian green tree [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Anticancer Antiparasitic
Pasteurella multocida
12-25 μg/mL
MIC
PaperThe solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida.
RECORD: Rec_0220700 VERIFIED: NO
Provenance & Taxonomy
Magnificent tree [Animal]
Caerin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
RECORD: Rec_0222829 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Caerin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
3-12 μg/mL
MIC
PMID10601876;34259550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10601876/
RECORD: Rec_0241704 VERIFIED: YES
Provenance & Taxonomy
Ranoidea splendida [Animal]
Caerin
30345
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV Infection inhibition
inhibition of HIV transfer by dendritic cells to T cells
12.6 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperAntimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells. | VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D. | J Virol. 2005 Sep;79(18):11598-606. | DOI:10.1128/JVI.79.18.11598-11606.2005 | PMID:16140737 PMID16140737 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16140737/
RECORD: Rec_0242453 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]
Caerin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
15 μg/mL
MIC
PMID10601876;34259550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10601876/
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