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MYP_063564
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Basic Information
DASamP2 a
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
14 amino acids
C83H149N25O15
Standard
Sequence
IKWKKLLRAAKRIL
Physicochemical Analysis
1737.23 Da
12.00
5.76
5.55
0.4112
-0.11
0.97
-0.22
47.96
153.57
0.0714
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
685.29
-1.26
26.0
21.0
63.0
123.0
2.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0360785 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals that this sequence is poorly similar (78.57%) to Polybia-MPI . K: 29%. GRAVY: -0.107; M Wt: 1737.242; M formula: C83H150N25O15; mol ex coeff: 5550. A peptide mutant of polybia-MPI with the following mutations: D2K, D8R, and Q12R. Chemical modification: C-termnal amidation
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus USA300 MRSA
6.2 μM
MIC
PaperDatabase screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300
RECORD: Rec_0402712 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
12.5 μM
MIC
PMID22445495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22445495/
RECORD: Rec_0408129 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals that this sequence is poorly similar (78.57%) to Polybia-MPI . K: 29%. GRAVY: -0.107; M Wt: 1737.242; M formula: C83H150N25O15; mol ex coeff: 5550. A peptide mutant of polybia-MPI with the following mutations: D2K, D8R, and Q12R. Chemical modification: C-termnal amidation
Bio-Activity Profile
Antimicrobial
Escherichia coli
3.1 μM
MIC
PaperDatabase screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300
RECORD: Rec_0418810 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals that this sequence is poorly similar (78.57%) to Polybia-MPI . K: 29%. GRAVY: -0.107; M Wt: 1737.242; M formula: C83H150N25O15; mol ex coeff: 5550. A peptide mutant of polybia-MPI with the following mutations: D2K, D8R, and Q12R. Chemical modification: C-termnal amidation
Bio-Activity Profile
Antimicrobial
Bacillus subtilis
12.5 μM
MIC
PaperDatabase screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300
RECORD: Rec_0424495 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
75 μM
Hemolysis
PMID22445495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22445495/
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