Peptide Database

Peptide NameMotilin(1–12)ghrelin(12–24)

Function Ontology

Gastrointestinal bioactivity ▸ Gastrointestinal motility

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC137H220N38O36

DescriptionStandard

        FVPIFTYGELQRVQQRKESKKPPAK
    

Molecular Weight2975.45 Da

Isoelectric Point (pI)10.17

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.1504

GRAVY Index-1.04

Hydrophobic Moment 0.48

Boman Index-0.26

Instability Index51.73

Aliphatic Index 58.40

Aromaticity 0.1200

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1227.79

LogP -10.02

H-bond Donors 41.0

H-bond Acceptors 40.0

Rotatable Bonds 99.0

Heavy Atoms 211.0

Ring Count 6.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0406001 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyMotilin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Gastrointestinal motility

TargetGPR38 agonist activity

Activity0.01-0.011 μM

MethodEC50

Half-LifeIntravenouly injected in Sprague-Dawley rats, in vivo; 348 s