Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length446 amino acids

Chemical FormulaC2177H3532N558O626S21

DescriptionStandard

        MFLCCWLALVALIPTTVSINPGVKVKLTEKGLEYGRDLGMATIQQKLKTIKVPDMSGEQRVSPIGKVHYSLTNMHIVNVGLPKSAVDLVPGTGVRLSITNAFISLQGNWRVKYLRIIKDSGSFDLNVNGLTITSSIAIKSDETGRPAVSSVNCAATVSKKPCCICPLVADAISDLNPHLKTLNVLAKVDPYAEIEYSMVSSPTVSKSSIDFSLKGEFYNIGKHQEPPFSPKPFTLAPQINNMLYIGVSAFTTNSAAFVYNKAGALSLAITDDMIPQSSPIRLNTRTFGAFIPQIAKRFPGLMMKLLVKTVKDPIITFETNNMTVQAIGTVTAYAIQPNATLSPLFVLNMDTSVSARVYVSGVKLAGAVTLNKMDLTLGTSYVGDFQVGSLDNILQMVLKVVVIPKLNVQLAKGYPLPTLGKMKLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight48212.06 Da

Isoelectric Point (pI)9.38

Net Charge (pH 7.0)13.79

Net Charge (pH 7.4) 13.19

Charge Density (pH 7.0) 0.0309

GRAVY Index0.24

Hydrophobic Moment 0.65

Boman Index0.17

Instability Index31.25

Aliphatic Index 105.29

Aromaticity 0.0695

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30745.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0351128 VERIFIED: NO

Provenance & Taxonomy

OrganismDicentrarchus labrax [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence