Peptide Database

Peptide NameR-spondin-3

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length251 amino acids

Chemical FormulaC1194H1955N383O367S25

DescriptionStandard

        QNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH
    

Molecular Weight28349.27 Da

Isoelectric Point (pI)9.54

Net Charge (pH 7.0)28.08

Net Charge (pH 7.4) 27.16

Charge Density (pH 7.0) 0.1119

GRAVY Index-1.07

Hydrophobic Moment 0.62

Boman Index-0.31

Instability Index48.13

Aliphatic Index 43.47

Aromaticity 0.0518

Extinction Coeff. Reduced 18450.00

Extinction Coeff. Oxidized 19825.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0250497 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsAsparagine residue at position 15 is N-linked glycosylated; disulfide bonds between cysteine residues at positions 127 and 169; 138 and 145; 178 and 185

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetLGR4 (Human); LGR5 (Human); LGR6 (Human)

Activity0.02 nM

MethodEC50