Peptide Database

Peptide NameLebetin 2 isoform alpha

Function Ontology

Cardiovascular

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ Cell Aggregation Inhibitor

Hormonal / Endocrine ▸ Hormone peptide

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC166H267N55O53S2

DescriptionStandard

        GDNKPPKKGPPNGCFGHKIDRIGSHSGLGCNKVDDNKG
    

Molecular Weight3945.36 Da

Isoelectric Point (pI)9.19

Net Charge (pH 7.0)2.91

Net Charge (pH 7.4) 2.57

Charge Density (pH 7.0) 0.0767

GRAVY Index-1.28

Hydrophobic Moment 0.65

Boman Index-0.22

Instability Index23.98

Aliphatic Index 38.42

Aromaticity 0.0263

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1742.26

LogP -24.34

H-bond Donors 58.0

H-bond Acceptors 60.0

Rotatable Bonds 132.0

Heavy Atoms 276.0

Ring Count 7.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0008462 VERIFIED: NO

Provenance & Taxonomy

OrganismVipera lebetina [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide14-30

Bio-Activity Profile

Function

Cell Aggregation Inhibitor

RECORD: Rec_0014231 VERIFIED: YES

Provenance & Taxonomy

OrganismMacrovipera lebetinus [Animal]

FamilyLebetin-2

Tax ID3148341

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide14-30

Bio-Activity Profile

Function

Hormone Endocrine Cardiovascular ACE inhibitory

Activity0.14 μM

MethodIC50

Half-LifeMammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0161547 VERIFIED: YES

Provenance & Taxonomy

OrganismMacrovipera lebetinus [Animal]

FamilyLebetin-2

Tax ID3148341

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide14-30

Bio-Activity Profile

Function

Hormone Endocrine Cardiovascular ACE inhibitory

Half-LifeMammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0371729 VERIFIED: YES

Provenance & Taxonomy

OrganismMacrovipera lebetina [Animal]

Familynatriuretic peptide family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide14-30

Bio-Activity Profile

Function

Toxin Venom natriuretic peptide family