Peptide Database

Peptide NameSLAY-screened peptide P3519

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC108H178N24O29S

DescriptionStandard

        TLLNVISNVLTSLLFICALFN
    

Molecular Weight2308.78 Da

Isoelectric Point (pI)5.18

Net Charge (pH 7.0)-0.61

Net Charge (pH 7.4) -0.82

Charge Density (pH 7.0) -0.0291

GRAVY Index1.74

Hydrophobic Moment 0.52

Boman Index0.56

Instability Index9.52

Aliphatic Index 180.95

Aromaticity 0.0952

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 855.51

LogP -5.42

H-bond Donors 30.0

H-bond Acceptors 30.0

Rotatable Bonds 74.0

Heavy Atoms 162.0

Ring Count 2.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0178988 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/