Peptide Database

Peptide NameDermaseptin sI

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Antiviral

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Reproductive biology ▸ Contraceptive activity ▸ Spermicidal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length79 amino acids

Chemical FormulaC383H634N102O124S5

DescriptionStandard

        MDILKKSLFLVLFLGLVSLSICEEEKRENEDEEKQEDDEQSEMKRALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ
    

Molecular Weight8812.07 Da

Isoelectric Point (pI)4.93

Net Charge (pH 7.0)-4.40

Net Charge (pH 7.4) -4.71

Charge Density (pH 7.0) -0.0557

GRAVY Index-0.37

Hydrophobic Moment 0.51

Boman Index-0.05

Instability Index49.23

Aliphatic Index 91.52

Aromaticity 0.0380

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3692.59

LogP -34.22

H-bond Donors 127.0

H-bond Acceptors 126.0

Rotatable Bonds 317.0

Heavy Atoms 614.0

Ring Count 5.0

Amide Bonds 83.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0187033 VERIFIED: NO

Provenance & Taxonomy

OrganismPhyllomedusa sauvagei [Animal]

FamilyDermaseptin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0310016 VERIFIED: YES