Peptide Database

Peptide NamePhD1 (PhD-1; Defensin-1; primates, mammals, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC167H282N62O37S6

DescriptionStandard

        RRICRCRIGRCLGLEVYFGVCFLHGRLARRCCR
    

Molecular Weight3942.81 Da

Isoelectric Point (pI)10.60

Net Charge (pH 7.0)7.79

Net Charge (pH 7.4) 7.45

Charge Density (pH 7.0) 0.2360

GRAVY Index0.15

Hydrophobic Moment 0.80

Boman Index-0.24

Instability Index44.82

Aliphatic Index 91.52

Aromaticity 0.0909

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1637.83

LogP -14.74

H-bond Donors 70.0

H-bond Acceptors 52.0

Rotatable Bonds 132.0

Heavy Atoms 272.0

Ring Count 4.0

Amide Bonds 32.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0082814 VERIFIED: YES

Provenance & Taxonomy

OrganismPapio hamadryas [Animal]

FamilyDefensin

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetCandida albicans

RECORD: Rec_0086134 VERIFIED: YES

Provenance & Taxonomy

OrganismPapio hamadryas [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal

Targetfungus Candida albicans

Activity2.3 μM

MethodMIC

RECORD: Rec_0090239 VERIFIED: YES

Provenance & Taxonomy

OrganismPapio hamadryas [Animal]

FamilyAlpha-defensin; Defensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli

RECORD: Rec_0131114 VERIFIED: YES

Provenance & Taxonomy

OrganismPapio hamadryas [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli

RECORD: Rec_0164083 VERIFIED: YES

Provenance & Taxonomy

OrganismPapio hamadryas [Animal]

FamilyDefensin

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetEscherichia coli

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