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MYP_063306
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Basic Information
PhD1 (PhD-1; Defensin-1; primates, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
33 amino acids
C167H282N62O37S6
Standard
Sequence
RRICRCRIGRCLGLEVYFGVCFLHGRLARRCCR
Physicochemical Analysis
3942.81 Da
10.60
7.79
7.45
0.2360
0.15
0.80
-0.24
44.82
91.52
0.0909
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1637.83
-14.74
70.0
52.0
132.0
272.0
4.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006378 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
PaperPubMed PMID: 16978151 PMID16978151 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16978151/
RECORD: Rec_0014061 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0016821 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
the Gram- bacterium Escherichia coli
1.6 μM
MIC
Paperalpha-Defensins from blood leukocytes of the monkey Papio hamadryas
RECORD: Rec_0042875 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Listeria monocytogenes
PaperPubMed PMID: 16978151 PMID16978151 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16978151/
RECORD: Rec_0043066 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
PMID16978151 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16978151/
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