Peptide Database

Peptide NameSLAY-screened peptide P1888

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC89H150N30O25

DescriptionStandard

        PNRAVRGFANISTTIPIGR
    

Molecular Weight2040.33 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)2.96

Net Charge (pH 7.4) 2.90

Charge Density (pH 7.0) 0.1557

GRAVY Index-0.14

Hydrophobic Moment 0.75

Boman Index-0.03

Instability Index26.62

Aliphatic Index 87.37

Aromaticity 0.0526

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 896.91

LogP -11.31

H-bond Donors 33.0

H-bond Acceptors 28.0

Rotatable Bonds 64.0

Heavy Atoms 144.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0303162 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/