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MYP_063222
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Basic Information
EBR24
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
11 amino acids
C61H101N19O18
Standard
Sequence
AEPERRNIKYL
Physicochemical Analysis
1388.57 Da
8.63
0.80
0.60
0.0727
-1.47
0.54
-0.49
137.92
80.00
0.0909
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
633.27
-4.93
22.0
19.0
46.0
98.0
2.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0107859 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperA novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase PMID12054767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054767/
RECORD: Rec_0250839 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
50 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperA novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase. | de Soultrait VR, Caumont A, Parissi V, Morellet N, Ventura M, Lenoir C, Litvak S, Fournier M, Roques B. | J Mol Biol. 2002 Apr 19;318(1):45-58. | DOI:10.1016/S0022-2836(02)00033-5 | PMID:12054767 PMID12054767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054767/
RECORD: Rec_0251738 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-end processing catalyzed by integrase
50 μM
IC50
PaperA novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase PMID12054767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054767/
RECORD: Rec_0268051 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
HeLa
50 μM
IC50
PaperA novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase. PMID12054767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054767/
RECORD: Rec_0269886 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 36.4%, C 63.6% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
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