Peptide Database

Peptide NameSLAY-screened peptide P5445

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC111H148N24O24S

DescriptionStandard

        PSLWGHWYWQPMILYSVA
    

Molecular Weight2234.57 Da

Isoelectric Point (pI)7.16

Net Charge (pH 7.0)0.04

Net Charge (pH 7.4) -0.07

Charge Density (pH 7.0) 0.0024

GRAVY Index0.16

Hydrophobic Moment 0.17

Boman Index0.44

Instability Index37.39

Aliphatic Index 86.67

Aromaticity 0.2778

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 735.30

LogP 0.05

H-bond Donors 27.0

H-bond Acceptors 26.0

Rotatable Bonds 61.0

Heavy Atoms 160.0

Ring Count 11.0

Amide Bonds 18.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0213513 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/