Peptide Database

Peptide NameArgireline

Function Ontology

Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-aging

Standard StatusStandard

Sequence Length6 amino acids

Chemical FormulaC32H57N13O12S

DescriptionStandard

        EEMQRR
    

Molecular Weight847.94 Da

Isoelectric Point (pI)6.24

Net Charge (pH 7.0)-0.16

Net Charge (pH 7.4) -0.33

Charge Density (pH 7.0) -0.0267

GRAVY Index-2.93

Hydrophobic Moment 0.64

Boman Index-1.12

Instability Index145.57

Aliphatic Index 0.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 450.31

LogP -4.90

H-bond Donors 16.0

H-bond Acceptors 13.0

Rotatable Bonds 31.0

Heavy Atoms 58.0

Ring Count 0.0

Amide Bonds 6.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0008190 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySNAP-25-derived peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermAcetylation

C-TermAmidation

Other ModsAcetylated cosmetic hexapeptide motif

Bio-Activity Profile

Function

Anti-aging Anti-melanogenic

TargetFemale subjects, aged 35-55 years (Randomized clinical trial)

MethodCell viability assay; Cytotoxicity assay; Cell proliferation assay; Immunofluorescence; qPCR; Clinical assessment; AFM; Enzyme activity assay

RECORD: Rec_0015766 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySNAP-25-derived peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermAcetylation

C-TermAmidation

Other ModsAcetylated cosmetic hexapeptide motif

Bio-Activity Profile

Function

Anti-aging Anti-melanogenic

TargetHaCaT keratinocyte line (In vitro)

MethodCell viability assay; Cytotoxicity assay; Cell proliferation assay; Immunofluorescence; qPCR; Clinical assessment; AFM; Enzyme activity assay

RECORD: Rec_0109796 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySNAP-25-derived peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermAcetylation

C-TermAmidation

Other ModsAcetylated cosmetic hexapeptide motif

Bio-Activity Profile

Function

Anti-aging Anti-melanogenic

TargetHuman primary skin fibroblasts (In vitro)

MethodCell viability assay; Cytotoxicity assay; Cell proliferation assay; Immunofluorescence; qPCR; Clinical assessment; AFM; Enzyme activity assay

RECORD: Rec_0243633 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySNAP-25-derived peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermAcetylation

C-TermAmidation

Other ModsAcetylated cosmetic hexapeptide motif

Bio-Activity Profile

Function

Anti-aging Anti-melanogenic

TargetHuman embryonic kidney HEK-293 cell line (In vitro)

MethodCell viability assay; Cytotoxicity assay; Cell proliferation assay; Immunofluorescence; qPCR; Clinical assessment; AFM; Enzyme activity assay

RECORD: Rec_0256588 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySNAP-25-derived peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermAcetylation

C-TermAmidation

Other ModsAcetylated cosmetic hexapeptide motif

Bio-Activity Profile

Function

Anti-aging Anti-melanogenic

TargetHuman neuroblastoma IMR-32 cell line (In vitro)

MethodCell viability assay; Cytotoxicity assay; Cell proliferation assay; Immunofluorescence; qPCR; Clinical assessment; AFM; Enzyme activity assay