Peptide Database

Peptide NameAntimicrobial peptide NK-lysin (NKL)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length129 amino acids

Chemical FormulaC618H1036N180O186S11

DescriptionStandard

        PGLAFSGLTPEHSALARAHPCDGEQFCQNLAPEDPQGDQLLQREELGLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKEKTGLI
    

Molecular Weight14316.65 Da

Isoelectric Point (pI)8.53

Net Charge (pH 7.0)3.08

Net Charge (pH 7.4) 2.76

Charge Density (pH 7.0) 0.0238

GRAVY Index-0.34

Hydrophobic Moment 0.87

Boman Index-0.08

Instability Index36.48

Aliphatic Index 90.00

Aromaticity 0.0233

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5908.02

LogP -59.37

H-bond Donors 208.0

H-bond Acceptors 202.0

Rotatable Bonds 495.0

Heavy Atoms 995.0

Ring Count 13.0

Amide Bonds 139.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0064650 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytotoxic Non-hemolytic

TargetPseudomonas aeruginosa (Gram-negative)

RECORD: Rec_0130591 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytotoxic Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0140039 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytotoxic Non-hemolytic

TargetB. megaterium

RECORD: Rec_0156550 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytotoxic Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0376903 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytotoxic Non-hemolytic

TargetA. calcoaceticus (Gram-negative)