Peptide Database

Peptide NameMetalnikowin-1 (Metalnikowin I; Insects, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC80H128N26O22S

DescriptionStandard

        VDKPDYRPRPRPPNM
    

Molecular Weight1838.10 Da

Isoelectric Point (pI)9.98

Net Charge (pH 7.0)1.73

Net Charge (pH 7.4) 1.52

Charge Density (pH 7.0) 0.1156

GRAVY Index-2.07

Hydrophobic Moment 0.23

Boman Index-0.61

Instability Index13.63

Aliphatic Index 19.33

Aromaticity 0.0667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 776.41

LogP -7.18

H-bond Donors 25.0

H-bond Acceptors 25.0

Rotatable Bonds 52.0

Heavy Atoms 129.0

Ring Count 6.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0384246 VERIFIED: YES

Provenance & Taxonomy

OrganismPalomena prasina [Animal]

Tax ID55431

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 IIIB | CEM-SS cells

Activity54.4 μM

MethodEC50

Half-LifeMammalian: 100 h; Yeast: >20 h; E. coli: >10 h

PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. | Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. | DOI:10.1128/AAC.01448-09 | PMID:20086159 PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/

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