Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2313H3730N600O665S19

DescriptionStandard

        MFLLKCLPLVALIAAAFSANPGVKIRLTQKGLEYGKQLGMASLLEKLKTAQIPDFSGKERVSPIGKVQYSLTNIHVVNLGLPQSSINLVPGSGVQLSISNAFISLRGNWRVKYLRFIKDSGSLDVNVNGLSISQTIAIKSDATGKPEASSAACSASVSSAKVKFHGGASWLYNLFSKFIDKALRKALEKQMCPLVAKSIADLNPRLKTLNVLAKVDKYAEIEYSMVSSPQISQPAIDLNLKGEFYNIGRHQEAPFPAPAFSLPAQSSNMIYIALSSFTPNSAGFVYNNAGVLSMYVTDDMIPRSSPIRLSTSTFGFFIPQIAQRFPGLMMKMLVKADKNPVVKFQPNVMTVDATATATAYAIQPNGTLSPLFVLNVDSSVSSQMSVSDLKLASRITLNKMSLSLGTSYVGDFKVNSLDNILQVILKLVVIPTVNVQLSKGYPLPALGKMKLVNTQLQIMQDYLMIGTDVQFTG
    

Molecular Weight51193.21 Da

Isoelectric Point (pI)9.68

Net Charge (pH 7.0)18.73

Net Charge (pH 7.4) 18.22

Charge Density (pH 7.0) 0.0396

GRAVY Index0.17

Hydrophobic Moment 0.85

Boman Index0.14

Instability Index38.13

Aliphatic Index 102.45

Aromaticity 0.0782

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 31985.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0337342 VERIFIED: NO

Provenance & Taxonomy

OrganismOryzias latipes [Plant]

FamilyBPI

Tax ID8090

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence