Peptide Database

Peptide NameDefensin alpha 5 (Defensin-5) (HD5(20-94)) [Cleaved into: HD5(23-94); HD5(29-94); HD5(56-94); HD5(63-94)]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Fungicidal activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length94 amino acids

Chemical FormulaC423H708N130O139S7

DescriptionStandard

        MRTIAILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRIGHCTILESLSGVCEISGRLYRLCCR
    

Molecular Weight10063.39 Da

Isoelectric Point (pI)6.54

Net Charge (pH 7.0)-0.45

Net Charge (pH 7.4) -0.83

Charge Density (pH 7.0) -0.0048

GRAVY Index0.06

Hydrophobic Moment 0.69

Boman Index0.01

Instability Index41.61

Aliphatic Index 98.83

Aromaticity 0.0319

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4386.94

LogP -54.54

H-bond Donors 162.0

H-bond Acceptors 147.0

Rotatable Bonds 344.0

Heavy Atoms 699.0

Ring Count 4.0

Amide Bonds 102.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0371448 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetPseudomonas aeruginosa (Gram-negative)

RECORD: Rec_0380647 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetS. typhimurium

RECORD: Rec_0381862 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetL. fermentum (Gram-positive)

RECORD: Rec_0397081 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetB. breve (Gram-positive)

RECORD: Rec_0399042 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)

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